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+ Resveratrol 24,000mg

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SUPPORTS HEALTHY AGEING

INCREASED NAD+ LEVELS

ANTIOXIDANT EFFECTS

INCREASED ENERGY METABOLISM

IMPROVED MITOCHONDRIAL HEALTH

PROMOTES VASCULAR AND LIVER HEALTH

ENHANCES DNA REPAIR  

SST4

REDEFINE AGEING

NMN combined with Resveratrol works synergistically to maximise the activation of sirtiuns, the most important anti-aging and longevity genes found in the human body. This super potent formula boosts NAD+ levels that are essential for energy, metabolism and maintenance of DNA repair.  When we boost NMN levels in the body, we enhance the biosynthesis of NAD+ and help restore declining levels of NAD+ as we age.

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WHAT IS SO SPECIAL ABOUT NAD+?

Without NAD+ in our cells, we would be dead in less than 30 seconds. It is responsible for multiple enzymatic processes which are critical to repairing DNA damage and creating energy. It is the failing of these enzymatic processes that slow down our DNA repair which in turn leads to aging. If we can maintain our DNA repair processes for longer we could expect to live longer and healthier.

 

Even though NAD+ is one of the most critical molecules in our bodies… there is a problem!

 

Have a look at this diagram which relates to levels of NAD+ in our bodies and a DNA damage marker. Pretty frightening:  

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Image by Warren Umoh

AS YOUR DNA DAMAGE INCREASES WITH AGE

IT IS REFLECTED IN:

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Saggy and

dull skin

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Reduction

in energy

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Degenerative

conditions

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Loss of

libido

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Fuzzy thinking

and memory loss

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Poor Sleep

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If you raise the NAD+ levels in your body and increase the DNA repair process you can slow and even reverse the ageing process. After entering the human body, high-quality NMN can quickly penetrate the cell membrane, thereby promoting the natural synthesis of NAD+ by the cell, and rapidly increasing the human body’s NAD+ levels.  

THE SOLUTION

Scientists have found a safe and natural way to restore healthy levels of NAD+ in our bodies. The solution is to use a natural precursor to generate the extra NAD+ in our bodies. There are two options. One is called NR which is short for Nicotinamide Riboside Chloride and the other is NMN which is short for Nicotinamide mononucleotide. Neurolab uses NMN based on the results from scientists from Washington University School of Medicine in St. Louis who provide compelling evidence that NMN is superior to NR in boosting NAD+ levels. NMN also absorbs better than NR and Neurolab include 5mg of Bioperine in our formula to further enhance absorption efficiency.

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NMN ABSORBS BETTER

THAN THE REST

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SYNERGISTIC INCLUSION OF

RESVERATROL

Many supplements come with just NMN, which is less effective to produce higher levels of NAD which the body needs to prevent cellular degeneration as we age. As a result our Neurolab formula includes 400mg of NMN with synergistic inclusion of 400mg of Resveratrol and 5mg of Bioperine. Research shows the addition of Resveratrol to NMN can better improve the performance of NMN in NAD+ synthesis up to 500%. Resveratrol works with NMN acting as an accelerator to produce better results in DNA repair. Resveratrol is needed to activate the sirtuin genes which protect our DNA and epigenome, while NMN is needed to fuel the sirtuins. BioPerine is used to enhance absorption rates of NMN and Reseveratrol.

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END RESULT

NMN IS NOW THE MOST ADVANCED NAD+ PRECURSOR SUPPLEMENT ON THE GLOBAL MARKET TODAY AND INCORPORATES THE LATEST VERIFIABLE SCIENCE. 

THE SCIENCE

David Sinclair is a professor at Harvard University who has been studying aging for the better part of his academic career. His main research interest is the epigenetics of aging, with a focus on epigenetic reprogramming of aging, NAD+ metabolism and sirtuins, and NAD+ precursors like NR and NMN. He is the author of the New York Times best-selling book on aging, “Lifespan: Why We Age – And Why We Don’t Have To”.

 

Professor Sinclair says we lose NAD+ as we age “and the resulting decline in sirtuin activity, is the primary reason our bodies develop diseases when we are old but not when we are young.”  He believes that increasing NAD+ levels naturally while aging may slow or reverse certain aging processes. Professor Sinclair takes NMN and resveratrol every morning for its NAD+ boosting effect and anti-ageing benefits.   

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INGRDIENTS

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NMN

Nicotinamide mononucleotide (NMN) is the main precursor of nicotinamide adenine dinucleotide (NAD+) — an essential enzyme for various critical cell functions, including metabolism, DNA repair, cell growth and survival. When we boost NMN levels in the body, we enhance the biosynthesis of NAD and help restore declining levels of NAD as we age. Neurolab use beta nicotinamide mononucleotide in our formula which is the active version of NMN and delivers superior results.

BIOPERINE

Bioperine is a patented black pepper extract that contains the active compound piperine. BioPerine is used to enhance absorption rates of ingredients.

RESVERATROL

Resveratrol (3,5,4′-trihydroxy-trans-stilbene) is a natural compound found in red grape skin, Japanese knotweed, peanuts, blueberries and some other berries. It is a powerful antioxidant that neutralises free radicals, which are a major cause of aging. Resveratrol has many health benefits such as protecting the heart and circulatory system, lowering cholesterol, and protecting against clots which can cause heart attacks. Resveratrol also plays a key role in the activation of the sirtuin genes, which assist with cellular health. Resveratrol is the accelerator pedal for the sirtuin genes (increasing their activation), and NMN (a precursor to NAD) as the fuel. Without the “fuel”, resveratrol won’t be as effective.

WHAT AGE IS SUITABLE TO TAKE NMN?

Although NMN can be taken by anyone 18 years and older it is really not necessary until someone is getting to age 30+ when NAD+ levels start to drop sharply. We suggest the following people will benefit from taking NMN:

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MIDDLE-AGED AND ELDERLY PEOPLE

Assist in improving various senile diseases, fatigue, poor sleep, vision loss, etc.

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THOSE WHO STAY UP LATE AND DRINKERS

Speed up the recovery of the body, relieve alcohol and protect the liver.

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PEOPLE WITH MAJOR DISEASES

Improve immunity and assist physical recovery.

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DEPRESSED AND IRRADIATED

Improve the repair ability of genes damaged by radiation, increase dopamine levels, and improve mood.

MIDDLE-AGED AND ELDERLY WOMEN

Whitening and beauty, firming the skin and delaying ageing.

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ATHLETES AND BODYBUILDERS

Improve ability level and reaction speed, and accelerate muscle growth.

PRODUCT QUALITY

We source our NMN from one of the world-leading suppliers of this ingredient. Our supplier is accredited to the ISO9001 international quality standard. We test every batch of NMN for identification and purity by an independent GMP-certified laboratory here in Australia. The minimum standard we have set for NMN purity is 99%.  

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UNDERSTAND HOW NEUROLAB NMN WORKS

SCIENTIFIC RESEARCH

  • Alessia Grozio, Kathryn F. Mills, Jun Yoshino, Santina Bruzzone, Giovanna Sociali, Kyohei Tokizane, Hanyue Cecilia Lei, Richard Cunningham, Yo Sasaki, Marie E. Migaud, Shin-ichiro Imai.  Slc12a8 is a nicotinamide mononucleotide transporter.  Nat Metab, 2019; DOI: 10.1038/s42255-018-0009-4.

  • Huang RX, Tao J. Nicotinamide mononucleotide attenuates glucocorticoid-induced osteogenic inhibition by regulating the SIRT1/PGC-1α signaling pathway. Mol Med Rep. 2020;22(1):145-154. doi:10.3892/mmr.2020.11116.

  • Lv H, Lv G, Chen C, Zong Q, Jiang G, Ye D, Cui X, He Y, Xiang W, Han Q, Tang L, Yang W, Wang H. NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion. Cell Metab. 2020 Nov 9. DOI: 10.1016/j.cmet.2020.10.021

  • Martin AS, Abraham DM, Hershberger KA, et al. Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model. JCI Insight. 2017;2(14):e93885. Published 2017 Jul 20. doi:10.1172/jci.insight.93885.

  • Hisayuki Amano, Arindam Chaudhury, Cristian Rodriguez-Aguayo, Lan Lu, Viktor Akhanov, Andre Catic, Yury V. Popov, Eric Verdin, Hannah Johnson, Fabio Stossi, David A. Sinclair, Eiko Nakamaru-Ogiso, Gabriel Lopez-Berestein, Jeffrey T. Chang, Joel R. Neilson, Alan Meeker, Milton Finegold, Joseph A. Baur, Ergun Sahin.  Telomere dysfunction induces sirtuin repression that drives telomere-dependent disease.  Cell Metab, 2019; DOI: 10.1016/j.cmet.2019.03.001.

  • Chen X, Amorim JA, Moustafa GA, Lee JJ, Yu Z, Ishihara K, Iesato Y, Barbisan P, Ueta T, Togka KA, Lu L, Sinclair DA, Vavvas DG. Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging (Albany NY). 2020 Dec 29;12. doi: 10.18632/aging.202453. Epub ahead of print. PMID: 33373320.

  • Omran HM, Almaliki MS. Influence of NAD+ as an ageing-related immunomodulator on COVID 19 infection: A hypothesis. J Infect Public Health. 2020 Sep;13(9):1196-1201. doi: 10.1016/j.jiph.2020.06.004. Epub 2020 Jun 7. PMID: 32534944; PMCID: PMC7275989.

  • Yoshida M, Satoh A, Lin JB, et al. Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice. Cell Metab. 2019;30(2):329-342.e5. doi:10.1016/j.cmet.2019.05.015.

  • Yoshino M, Yoshino J, Kayser BD, Patti G, Franczyk MP, Mills KF, Sindelar M, Pietka T, Patterson BW, Imai SI, Klein S. Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women. Science. 2021 Apr 22:eabe9985. doi: 10.1126/science.abe9985. Epub ahead of print. PMID: 33888596.

  • Sanli Xing, Yiran Hu, Xujiao Huang, Dingzhu Shen, Chuan Chen. Nicotinamide phosphoribosyl transferase related signalling pathway in early Alzheimer’s disease mouse models.Shanghai Geriatric Institute of Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200031, P.R. China (2019) doi: 10.3892/mmr.2019.10782.

  • Xie X, Yu C, Zhou J, et al. Nicotinamide mononucleotide ameliorates the depression-like behaviors and is associated with attenuating the disruption of mitochondrial bioenergetics in depressed mice. J Affect Disord. 2020;263:166-174. doi:10.1016/j.jad.2019.11.147

  • Liang Shu, Xiaolei Shen, Yaxue Zhao, Xinwei He, Jiawen Yin, Jingjing Su, Qiang Li, Jianren Liu.  Mechanisms of transformation of nicotinamide mononucleotides to cerebral infarction hemorrhage based on MCAO model.  Saudi J Biol Sci, 2020; DOI: 10.1016/j.sjbs.2019.12.023.

  • Yang L, Lin X, Tang H, Fan Y, Zeng S, Jia L, Li Y, Shi Y, He S, Wang H, Hu Z, Gong X, Liang X, Yang Y, Liu X. Mitochondrial DNA mutation exacerbates female reproductive aging via impairment of the NADH/NAD+ redox. Aging Cell. 2020 Sep;19(9):e13206. doi: 10.1111/acel.13206.

  • Assiri MA, Ali HR, Marentette JO, Yun Y, Liu J, Hirschey MD, Saba LM, Harris PS, and Fritz KS.  Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease.  Hum Genomics, 2019; DOI: 10.1186/s40246-019-0251-1.

  • Jia Y, Kang X, Tan L, Ren Y, Qu L, Tang J, Liu G, Wang S, Xiong Z and Yang L (2021) Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence. Front. Physiol. 12:649547. doi: 10.3389/fphys.2021.649547.

  • Zong Z, Liu J, Wang N, Yang C, Wang Q, Zhang W, Chen Y, Liu X, Deng H. Nicotinamide mononucleotide inhibits hepatic stellate cell activation to prevent liver fibrosis via promoting PGE2 degradation. Free Radic Biol Med. 2020 Nov 19:S0891-5849(20)31626-9. doi: 10.1016/j.freeradbiomed.2020.11.014. Epub ahead of print. PMID: 33220424.

  • Meng YF, Pu Q, Dai SY, Ma Q, Li X, Zhu W. Nicotinamide Mononucleotide Alleviates Hyperosmolarity-Induced IL-17a Secretion and Macrophage Activation in Corneal Epithelial Cells/Macrophage Co-Culture System. J Inflamm Res. 2021 Feb 22;14:479-493. doi: 10.2147/JIR.S292764. PMID: 33658825; PMCID: PMC7917392.

  • Li J, Bonkowski MS, Moniot S, et al. A conserved NAD+ binding pocket that regulates protein-protein interactions during aging. Science. 2017;355(6331):1312-1317. doi:10.1126/science.aad8242.

  • Miao Y, Li X, Shi X, Gao Q, Chen J, Wang R, Fan Y, Xiong B. Nicotinamide Mononucleotide Restores the Meiotic Competency of Porcine Oocytes Exposed to Ethylene Glycol Butyl Ether. Front Cell Dev Biol. 2021 Feb 2;9:628580. doi: 10.3389/fcell.2021.628580.

  • Mills et al., 2016, Cell Metabolism 24, 795–806, December 13, 2016 ª 2016 Elsevier Inc. DOI: doi.org/10.1016/j.cmet.2016.09.013.

  • Gomes AP, Price NL, Ling AJ, et al. Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. Cell. 2013;155(7):1624-1638. doi:10.1016/j.cell.2013.11.037.

  • Yamamoto T, Byun J, Zhai P, Ikeda Y, Oka S, et al. (2014) Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion. PLoS ONE 9(6): e98972. doi:10.1371/journal.pone.0098972.

  • de Picciotto NE, Gano LB, Johnson LC, et al. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016;15(3):522-530. doi:10.1111/acel.12461.

  • Keisuke Okabe, Keisuke Yaku, Kazuyuki Tobe, Takashi Nakagawa. Implications of altered NAD metabolism in metabolic disorders. J Biomed Sci, 2019; DOI: 10.1186/s12929-019-0527-8.

  • Uddin GM, Youngson NA, Sinclair DA, Morris MJ. Head to Head Comparison of Short-Term Treatment with the NAD(+) Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice. Front Ph.

  • Uchida R, Saito Y, Nogami K, et al. Epigenetic silencing of Lgr5 induces senescence of intestinal epithelial organoids during the process of aging [published correction appears in NPJ Aging Mech Dis. 2019 Mar 7;5:5]. NPJ Aging Mech Dis. 2018;5:1. Published 2018 Dec 1. doi: 10.1038/s41514-018-0031-5.

  • Li Y, Ma X, Li J, et al. Corneal denervation causes epithelial apoptosis through inhibiting NAD. biosynthesis. Invest Ophthalmol Vis Sci. 2019;60:3538–3546. https://doi.org/10.1167/iovs.19-26909.

  • Yoo KH, Tang JJ, Rashid MA, Cho CH, Corujo-Ramirez A, Choi J, Bae MG, Brogren D, Hawse JR, Hou X, Weroha SJ, Oliveros A, Kirkeby LA, Baur JA, Jang MH. Nicotinamide mononucleotide prevents cisplatin-induced cognitive impairments. Cancer Res. 2021 Mar 26:canres.3290.2020. doi: 10.1158/0008-5472.CAN-20-3290.

  • Forte M, Bianchi F, Cotugno M, Marchitti S, De Falco E, Raffa S, Stanzione R, Di Nonno F, Chimenti I, Palmerio S, Pagano F, Petrozza V, Micaloni A, Madonna M, Relucenti M, Torrisi MR, Frati G, Volpe M, Rubattu S, Sciarretta S. Pharmacological restoration of autophagy reduces hypertension-related stroke occurrence. Autophagy. 2020 Aug;16(8):1468-1481. doi: 10.1080/15548627.2019.1687215. Epub 2019 Nov 12. PMID: 31679456; PMCID: PMC7469607.

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